Enantiomers of warfarin and vitamin K1 metabolism.
نویسندگان
چکیده
منابع مشابه
Effect of warfarin on the metabolism of phylloquinone (vitamin K1):dose-response relationships in man.
Summarg 1. The dose-response relationship between the oral anticoagulant, warfarin, and its effect on the metabolism of phylloquinone (vitamin K,) has been examined in normal male volunteer subjects. 2. In each study the subject received a single, oral dose of warfarin and, 2 h later, an intravenous injection of [l ',2'-3H2 Jphylloquinone. Changes in the metabolism of phylloquinone were assesse...
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Warfarin, a coumarin vitamin K antagonist, is the most widely prescribed anticoagulant agent for the control and prevention of atrial fibrillation-related thrombus formation, stroke, and arterial and venous thrombembolism (Hirsh J et al., 1998). The recommend warfarin therapy consists of the lowest dose required to maintain the target international normalized ratio (INR) because of the drug’s n...
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Vitamin E is recognized as an essential vitamin since its discovery in 1922. Most vegetable oils contain a mixture of tocopherols and tocotrienols in the vitamin E composition. Structurally, tocopherols and tocotrienols share a similar chromanol ring and a side chain at the C-2 position. Owing to the three chiral centers in tocopherols, they can appear as eight different stereoisomers. Plant so...
متن کاملVitamin K-dependent carboxylation and vitamin K epoxidation. Evidence that the warfarin-sensitive microsomal NAD(P)H dehydrogenase reduces vitamin K1 in these reactions.
Passage of a Triton X-100-solubilized microsomal systems in vitro that are used to study these reactions is the warfarin-sensitive NAD(P)H dehydrogenase.
متن کاملPhylloquinone (vitamin K1) content of vegetables
Assessment of vitamin K (VK) dietary intakes has been limited by incomplete VK food composition data for the US food supply. The phylloquinone (VK-1 or vitamin K1) concentrations of a variety of geographically representative vegetables (n 1⁄4 218) were determined by reversed-phase high performance liquid chromatography with fluorescent detection. Green leafy and flower vegetables including broc...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1986
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1986.tb02966.x